Professor Guoping (Sam) Gu is interested in molecular mechanisms of epigenetic inheritance. A growing body of evidence indicates that non-DNA sequence information (i.e., epigenetic information) acquired in ancestral generations can be heritable and have a phenotypic effect in descendants. The ability of transmitting epigenetic information through cell cycle and generational boundaries is an essential component of gene regulation and developmental control, yet the molecular mechanisms remain elusive. Professor Gu focuses on one mechanism that leads to a heritable epigenetic effect: RNA-induced chromatin modification that can last for multiple generations after the initial RNA exposure in C. elegans. Combining genetics, molecular biology and computational approaches, he studies how RNA triggers an epigenetic memory and how RNA-induced epigenetic signals are transmitted through generational boundaries.